Tetrabutylammonium Hydroxide

HCID 2723671CAS 2052-49-5

Basic information

Standard SMILES
CCCC[N+](CCCC)(CCCC)CCCC.[OH-]
InChIKey
VDZOOKBUILJEDG-UHFFFAOYSA-M
Molecular formula
C16H37NO
Average molar mass
259.47 g/mol
Monoisotopic mass
259.2875148

Names & identifiers

Preferred name
Tetrabutylammonium Hydroxide
IUPAC
tetrabutylazanium hydroxide
English name
Tetrabutylammonium hydroxide
Molecular formula
C16H37NO
Molecular weight
259.47

Names & synonyms

Tetrabutylammonium hydroxide2052-49-51-Butanaminium, N,N,N-tributyl-, hydroxide1-Butanaminium, N,N,N-tributyl-, hydroxide (1:1)68I858J9S1DTXSID8062155RefChem:188411DTXCID1036337218-147-6Tetra-n-butylammonium hydroxidetetrabutylazanium;hydroxidetetrabutyl ammonium hydroxide
Show more names
TBAHTBAOHTBHTBAOxn-Bu4NOHaqueoussolutionTetrabutylammonium Hydroxide (10% in Water)Tetrabutylammonium Hydroxide (37% in Methanol)Tetrabutylammonium hydroxide 40% methanol solution
tetrabutyl-ammonium hydroxideMFCD00009425tetra-n-butyl ammonium hydroxideTetrabutylammonium Hydroxide (~50% in water)tetrabutylazanium hydroxideTetrabutylammoniumhydroxideAmmonium, tetrabutyl-, hydroxideTetrabutylammonium Hydroxide (1.0M in Methanol)

Database identifiers

CAS
2052-49-5、65201-77-6
PubChem CID
2723671
DTXSID
DTXSID8062155
ChEMBL
CHEMBL1078154
UNII
68I858J9S1
EC Number
218-147-6

Properties

Computed structural properties

Topological polar surface area
1 Ų
Hydrogen bond donors
1
Hydrogen bond acceptors
1
Rotatable bonds
12
Heavy atoms
18

Experimental & physicochemical properties

Density0.968 @25 °C
Physical Description · 2 items

Liquid

55% Aqueous solution: Colorless liquid; [Alfa Aesar MSDS]

Physicochemical properties

Melting point
27 · 27-30 °C(lit.)
Boiling point
100 °C · 100 °C
Density
0.995 · 0.995
vapor density
1 · 1 (vs air)
vapor pressure
2.3 kPa · 2.3 kPa (@ 20°C)
refractive index
1.4 · 1.4

Safety & regulation

GHS classification

GHS Classification · 6 items

This chemical does not meet GHS hazard criteria for 11.5% (43 of 373) of reports.

Danger

H226 (51.7%): Flammable liquid and vapor [Warning Flammable liquids];H302 (52%): Harmful if swallowed [Warning Acute toxicity, oral];H314 (88.2%): Causes severe skin burns and eye damage [Danger Skin corrosion/irritation];H318 (52.8%): Causes serious eye damage [Danger Serious eye damage/eye irritation]

P210, P233, P240, P241, P242, P243, P260, P264, P264+P265, P270, P280, P301+P317, P301+P330+P331, P302+P361+P354, P303+P361+P353, P304+P340, P305+P354+P338, P316, P317, P321, P330, P363, P370+P378, P403+P235, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 373 reports by companies from 14 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.;Reported as not meeting GHS hazard criteria per 43 of 373 reports by companies.;There are 13 notifications provided by 330 of 373 reports by companies with hazard statement code(s).;Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website.

Hazard information

Regulatory Information · 4 items

Chemical: 1-Butanaminium, N,N,N-tributyl-, hydroxide

1-Butanaminium, N,N,N-tributyl-, hydroxide (1:1) is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of 1-Butanaminium, N,N,N-tributyl-, hydroxide (1:1) are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)

Status: Active Update: 13-09-2022 https://echa.europa.eu/registration-dossier/-/registered-dossier/19067

1-Butanaminium, N,N,N-tributyl-, hydroxide: Does not have an individual approval but may be used under an appropriate group standard

Other Safety InformationIMAP assessments - 1-Butanaminium, N,N,N-tributyl-, hydroxide: Human health tier II assessment
Hazards Summary55% Aqueous solution: Causes burns; Inhalation may cause corrosive injuries to upper respiratory tract and lungs; [Alfa Aesar MSDS]
Hazard Classes and Categories · 2 items

Flam. Liq. 3 (51.7%);Acute Tox. 4 (52%);Skin Corr. 1B (88.2%);Eye Dam. 1 (52.8%)

Acute toxicity (ingestion) - category 4;Acute toxicity (dermal) - category 4;Skin corrosion - category 1

Safety & protection

Protective Action Criteria (PAC) · 3 items

1.2 [mg/m3]

13 [mg/m3]

79 [mg/m3]

Toxicology

Adverse EffectsDermatotoxin - Skin burns.;Toxic Pneumonitis - Inflammation of the lungs induced by inhalation of metal fumes or toxic gases and vapors.

Regulatory information

Regulatory Information · 4 items

Chemical: 1-Butanaminium, N,N,N-tributyl-, hydroxide

1-Butanaminium, N,N,N-tributyl-, hydroxide (1:1) is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of 1-Butanaminium, N,N,N-tributyl-, hydroxide (1:1) are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)

Status: Active Update: 13-09-2022 https://echa.europa.eu/registration-dossier/-/registered-dossier/19067

1-Butanaminium, N,N,N-tributyl-, hydroxide: Does not have an individual approval but may be used under an appropriate group standard

Safety data

F
9-34
PPE
Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter
wgk
1
tsca
TSCA listed
rtecs
BS5425000
ridadr
UN 3267 8/PG 2

Chemistry & industry

Pharmacology

MeSH Pharmacological Classification · 1 item

Purifying or cleansing agents, usually salts of long-chain aliphatic bases or acids, that exert cleansing (oil-dissolving) and antimicrobial effects through a surface action that depends on possessing both hydrophilic and hydrophobic properties.

Uses & manufacturing

U.S. Production2023: 550,000 - <700,000 lb;2022: 400,000 - <550,000 lb;2021: 550,000 - <700,000 lb;2020: 400,000 - <550,000 lb
Industry UsesChemical reaction regulator;Plating agent;Catalyst;Not Known or Reasonably Ascertainable;Laboratory chemicals;Drier;Intermediate
General Manufacturing Information · 2 items

Computer and Electronic Product Manufacturing;Synthetic Rubber Manufacturing;Pesticide, Fertilizer, and Other Agricultural Chemical Manufacturing;Pharmaceutical and Medicine Manufacturing;All Other Basic Organic Chemical Manufacturing;Miscellaneous Manufacturing;All Other Chemical Product and Preparation Manufacturing;Photographic Film, Paper, Plate, and Chemical Manufacturing;Not Known or Reasonably Ascertainable

1-Butanaminium, N,N,N-tributyl-, hydroxide (1:1): ACTIVE

Applications · 2 items

UsesTetrabutylammonium hydroxide(TBAOH) is a quaternary ammonium salt mainly used as a strong base and phase-transfer catalyst. TBAOH may be used as an ion-pairing reagent in mobile phase preparation for reverse phase ion-pair high performance liquid chromatography during chromium (III) and chromium (VI) determination.

General DescriptionThe product is 54.0-56.0% solution of tetrabutylammonium hydroxide in H2O. Tetrabutylammonium hydroxide has been synthesized from tetrabutylammonium iodide. TBAOH dissolved in anhydrous isopropyl alcohol is widely employed as titrant for weak acids.

Preparation methods

PreparationTetrabutylammonium hydroxide was prepared by the ion exchange between gel type strong basic anion exchange resin(OH-) and aqueous solution of tetrabutylammonium bromide.

Suppliers50 total

国药集团化学试剂有限公司86-21-63210123 · [email protected]
梯希爱(上海)化成工业发展有限公司021-67121386 · [email protected]
上海阿拉丁生化科技股份有限公司400-6206333 13167063860 · [email protected]
爱斯特(成都)生物制药股份有限公司+86-28-85122536 85324413 · [email protected]
上海如吉生物科技发展有限公司+86-21-65211385-8001 36031160 · [email protected]

Related reactions

397 records

Linked notes

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