反应详情

10 g of 3-hydroxy-4-nitro-phthalide are dissolved in 100 ml of tetrahydrofuran and, after addition of 1 g of palladium on barium sulphate (5%), the mixture is hydrogenated at atmospheric pressure and 20°-25° C. The catalyst is filtered off and the filtrate is concentrated. The evaporation residue is stirred with ether and filtered off with suction. 5.8 g (68.5% of theory) of a colourless substance of melting point 280°-285° C. (dec.) are obtained.

1. customis hydrogenated at atmospheric pressure and 20°-25° C
2. filtrationThe catalyst is filtered off
3. concentrationthe filtrate is concentrated
4. filtrationfiltered off with suction
5. custom5.8 g (68.5% of theory) of a colourless substance of melting point 280°-285° C. (dec.) are obtained