反应详情

4.2 g of 1-(N,N-dimethylamino)-2-(2-trifluoromethylbenzoyl)ethene and 2.6 g of triethylamine were added to 50 ml of benzene. 2.4 g of methoxycarbonylsulfenyl chloride dissolved in 10 ml of benzene was added dropwise to the solution obtained above under cooling in an ice-bath. After completion of the addition, the reaction mixture was stirred at room temperature for 1 hour. After completion of the reaction, the solvent was distilled away under reduced pressure. After adding an aqueous solution of sodium hydrogencarbonate, the mixture was extracted with ether. Thus 5.0 g of 1-methoxycarbonylthio-1-(2-trifluoromethylbenzoyl)-2-(N,N-dimethylamino)ethene was obtained (Compound 209).

1. additionwas added dropwise to the solution
2. customobtained above
3. temperatureunder cooling in an ice-bath
4. additionAfter completion of the addition
5. customAfter completion of the reaction
6. distillationthe solvent was distilled away under reduced pressure
7. additionAfter adding an aqueous solution of sodium hydrogencarbonate
8. extractionthe mixture was extracted with ether