Ethanol → 2-Benzyloxymethyl-4(3H)-pteridinone

HRID 326839Notes

Reaction equation

HRID 326839 reaction equation
N[C:2]1[C:11]2[C:6](=[N:7][CH:8]=[CH:9][N:10]=2)[N:5]=[C:4]([CH2:12][O:13][CH2:14][C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)[N:3]=1.C([OH:23])C>[OH-].[Na+]>[CH2:14]([O:13][CH2:12][C:4]1[NH:3][C:2](=[O:23])[C:11]2[C:6](=[N:7][CH:8]=[CH:9][N:10]=2)[N:5]=1)[C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1

Participants

4

Reactant 2

HCID 702EthanolHCID 107782294-Amino-2-(benzyloxymethyl)pteridine

Product 1

HCID 1354616972-Benzyloxymethyl-4(3H)-pteridinone

Reagents, catalysts & solvents 1

HCID 14798Sodium HydroxideSolvent

Procedure

Obtained using the procedure described in section b of Example 9, starting with 10.0 g (0.037 mole) of crude 4-amino-2-(benzyloxymethyl)pteridine in 300 ml of 5% aqueous sodium hydroxide. Heating time: 2 hours at 80° C. Yld: 8.2 g (83%), m.p. 157°-159° C. (ethanol).

Workup

  1. customObtained
  2. temperatureHeating time
  3. custom2 hours
  4. customat 80° C

Sources & evidence

ORD record
ord-61a7494901f54b37947756cbcfb90b9f
Source dataset
uspto-grants-1993_12
Patent number
US05270465

Reaction notes

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