Ethanol → 2-Isopropoxymethyl-4(3H)-pteridinone

HRID 326844Notes

Reaction equation

HRID 326844 reaction equation
N[C:2]1[C:11]2[C:6](=[N:7][CH:8]=[CH:9][N:10]=2)[N:5]=[C:4]([CH2:12][O:13][CH:14]([CH3:16])[CH3:15])[N:3]=1.C([OH:19])C>[OH-].[Na+]>[CH:14]([O:13][CH2:12][C:4]1[NH:3][C:2](=[O:19])[C:11]2[C:6](=[N:7][CH:8]=[CH:9][N:10]=2)[N:5]=1)([CH3:16])[CH3:15]

Participants

4

Reactant 2

HCID 702EthanolHCID 105130704-Amino-2-(isopropoxymethyl)pteridine

Product 1

HCID 1355283222-Isopropoxymethyl-4(3H)-pteridinone

Reagents, catalysts & solvents 1

HCID 14798Sodium HydroxideSolvent

Procedure

Obtained using the procedure described in section d of Example 2, starting with 4.5 g (0.0205 mole) of 4-amino-2-(isopropoxymethyl)pteridine in 150 ml of 5% aqueous sodium hydroxide. Heating time: 2 hours at 80° C. Yld: 3.0 g (66%), m.p. 198°-199° C. (ethanol).

Workup

  1. customObtained
  2. temperatureHeating time
  3. custom2 hours
  4. customat 80° C

Sources & evidence

ORD record
ord-15c16d4e0c0b495d98afbcfc12788beb
Source dataset
uspto-grants-1993_12
Patent number
US05270465

Reaction notes

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