3-Aminopyrazine-2-carbonitrile → HCID 10731668, compound

HRID 326857Notes

Reaction equation

HRID 326857 reaction equation
[NH2:1][C:2]1[C:3]([C:8]#[N:9])=[N:4][CH:5]=[CH:6][N:7]=1.[CH3:10][O:11][C:12]1[CH:22]=[CH:21][C:15]([O:16][CH2:17][C:18](N)=[NH:19])=[CH:14][CH:13]=1.C(O)C.CN(C)C=O>C(O)C>[NH2:9][C:8]1[C:3]2[C:2](=[N:7][CH:6]=[CH:5][N:4]=2)[N:1]=[C:18]([CH2:17][O:16][C:15]2[CH:21]=[CH:22][C:12]([O:11][CH3:10])=[CH:13][CH:14]=2)[N:19]=1

Participants

5

Reactant 3

HCID 8176993-Aminopyrazine-2-carbonitrileHCID 106549552-(4-Methoxyphenoxy)ethanimidamideHCID 19794673N,N-dimethylformamide ethanol

Product 1

HCID 10731668HCID 10731668, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Obtained using the procedure described in section c of Example 2, starting with 9.8 g (0.082 mole) of 3-amino-2-pyrazinecarbonitrile and the above solution of 2-(4-methoxyphenoxy)acetamidine in absolute ethanol. Refluxing time: 2 hours. Yld: 5.5 g (24%), m.p. 238°-240° C. (ethanol/N,N-dimethylformamide).

Workup

  1. customObtained
  2. temperatureRefluxing time
  3. custom2 hours

Sources & evidence

ORD record
ord-eab668f2645641b4b8e48be7273810d4
Source dataset
uspto-grants-1993_12
Patent number
US05270465

Reaction notes

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