Sodium Bicarbonate → HCID 19736211, compound

Participants

Reaction Steps

10.2 g (0.121 mole) of sodium hydrogen carbonate are added to a suspension of 40.0 g (0.127 mole) of ethyl 2-(4-acetyl-3-hydroxy-2-propylphenoxy)acetimidate hydrochloride in 1 l of chloroform, and this mixture is stirred for 1 hour. The solid is removed by filtration and the filtrate is concentrated to dryness under reduced pressure. The residue obtained is extracted with a mixture of 100 ml of hexane and 100 ml of isopropyl ether under reflux. This extract, concentrated under reduced pressure, is recrystallized from hexane. Yld: 25.0 g (70%), m.p. 50°-52° C.

Provenance & Evidence