Sodium Bicarbonate → HCID 19736211, compound

HRID 326867Notes

Reaction equation

HRID 326867 reaction equation
C(=O)([O-])O.[Na+].Cl.[C:7]([C:10]1[CH:22]=[CH:21][C:13]([O:14][CH2:15][C:16](=[NH:20])[O:17][CH2:18][CH3:19])=[C:12]([CH2:23][CH2:24][CH3:25])[C:11]=1[OH:26])(=[O:9])[CH3:8]>C(Cl)(Cl)Cl>[C:7]([C:10]1[CH:22]=[CH:21][C:13]([O:14][CH2:15][C:16](=[NH:20])[O:17][CH2:18][CH3:19])=[C:12]([CH2:23][CH2:24][CH3:25])[C:11]=1[OH:26])(=[O:9])[CH3:8]

Participants

4

Reactant 2

HCID 516892Sodium BicarbonateHCID 19736210HCID 19736210, compound

Product 1

HCID 19736211HCID 19736211, compound

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

10.2 g (0.121 mole) of sodium hydrogen carbonate are added to a suspension of 40.0 g (0.127 mole) of ethyl 2-(4-acetyl-3-hydroxy-2-propylphenoxy)acetimidate hydrochloride in 1 l of chloroform, and this mixture is stirred for 1 hour. The solid is removed by filtration and the filtrate is concentrated to dryness under reduced pressure. The residue obtained is extracted with a mixture of 100 ml of hexane and 100 ml of isopropyl ether under reflux. This extract, concentrated under reduced pressure, is recrystallized from hexane. Yld: 25.0 g (70%), m.p. 50°-52° C.

Workup

  1. customThe solid is removed by filtration
  2. concentrationthe filtrate is concentrated to dryness under reduced pressure
  3. customThe residue obtained
  4. extractionis extracted with a mixture of 100 ml of hexane and 100 ml of isopropyl ether
  5. temperatureunder reflux
  6. concentrationThis extract, concentrated under reduced pressure
  7. customis recrystallized from hexane

Sources & evidence

ORD record
ord-67f1b16ef03c439f8a8783968bd7c6bf
Source dataset
uspto-grants-1993_12
Patent number
US05270465

Reaction notes

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