Morpholine → 2-Morpholin-4-yl-5-(propane-1-sulfonyl)-benzoic acid

HRID 32687Notes

Reaction equation

HRID 32687 reaction equation
[CH3:1][S:2]([C:5]1[CH:6]=[CH:7][C:8]([N:14]2[CH2:18][CH2:17][CH2:16][CH2:15]2)=[C:9]([CH:13]=1)[C:10]([OH:12])=[O:11])(=[O:4])=[O:3].Cl[C:20]1C=CC(S(C(C)C)(=O)=O)=C[C:21]=1C(O)=O.N1CC[O:38]CC1>>[N:14]1([C:8]2[CH:7]=[CH:6][C:5]([S:2]([CH2:1][CH2:20][CH3:21])(=[O:4])=[O:3])=[CH:13][C:9]=2[C:10]([OH:12])=[O:11])[CH2:18][CH2:17][O:38][CH2:16][CH2:15]1

Participants

4

Reactant 3

HCID 8083MorpholineHCID 431409992-Chloro-5-(propane-2-sulfonyl)benzoic acidHCID 597934895-Methanesulfonyl-2-pyrrolidin-1-yl-benzoic acid

Product 1

HCID 597935482-Morpholin-4-yl-5-(propane-1-sulfonyl)-benzoic acidYield 62%

Procedure

The title compound was synthesised according to the procedure described for the synthesis of 5-Methanesulfonyl-2-pyrrolidin-1-yl-benzoic acid from 2-Chloro-5-(propane-2-sulfonyl)-benzoic acid and morpholine and obtained in 62% yield. MS (m/e): 312.2 (MH−, 100%).

Workup

  1. customobtained in 62% yield

Sources & evidence

ORD record
ord-af0df1dc68cc4f339e1e4766aefa9d35
Source dataset
uspto-grants-2008_09
Patent number
US07427612B2

Reaction notes

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