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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 32687Generated: October 29, 2026

Morpholine → 2-Morpholin-4-yl-5-(propane-1-sulfonyl)-benzoic acid

https://huagongshe.com/reaction/32687

Reaction equation

Participants

RoleNameHCIDCharge
ReactantMorpholineHCID 8083—
Reactant2-Chloro-5-(propane-2-sulfonyl)benzoic acidHCID 43140999—
Reactant5-Methanesulfonyl-2-pyrrolidin-1-yl-benzoic acidHCID 59793489—
Product2-Morpholin-4-yl-5-(propane-1-sulfonyl)-benzoic acidHCID 5979354862%

Reaction Steps

The title compound was synthesised according to the procedure described for the synthesis of 5-Methanesulfonyl-2-pyrrolidin-1-yl-benzoic acid from 2-Chloro-5-(propane-2-sulfonyl)-benzoic acid and morpholine and obtained in 62% yield. MS (m/e): 312.2 (MH−, 100%).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07427612B2
Source datasetuspto-grants-2008_09
ORD IDord-af0df1dc68cc4f339e1e4766aefa9d35
Source noteuspto-grants-2008_09