反应详情

3.5 g (0.024 mole) of a 40% aqueous solution of glyoxal are added to a suspension of 3.7 g (0.020 mole) of 5,6-diamino-2-(ethoxymethyl)-4(3H)-pyrimidinone in 30 ml of water. The mixture is brought gradually to reflux and kept refluxing for 1 hour. After the addition of Norit, refluxing is continued for a further 10 minutes and the reaction mixture is then filtered. The aqueous solution obtained is extracted with dichloromethane. These organic extracts are treated as in section c of Example 25. Yld: 2.5 g (61%), m.p. 168°-169° C. The product is identical to that obtained in Example 1.

1. temperatureto reflux
2. temperaturekept refluxing for 1 hour
3. temperaturerefluxing
4. filtrationthe reaction mixture is then filtered
5. customThe aqueous solution obtained
6. extractionis extracted with dichloromethane
7. additionThese organic extracts are treated as in section c of Example 25
8. customthat obtained in Example 1