反应详情

To a stirred suspension of 414 parts of 2-bromo-3-nitrobenzoic acid in 653 parts of methylbenzene there were added 440 parts of thionyl chloride. The whole was refluxed for 6 hours, cooled and left overnight. The reaction mixture was treated with activated charcoal, filtered over diatomaceous earth and evaporated. The residual oil was triturated with 396 parts of hexane (2×). The product was filtered off, washed with hexane and dried, yielding 363 parts (81.7%) of 2-bromo-3-nitrobenzoyl chloride (interm. 3).

1. temperatureThe whole was refluxed for 6 hours
2. temperaturecooled
3. filtrationfiltered over diatomaceous earth
4. customevaporated
5. customThe residual oil was triturated with 396 parts of hexane (2×)
6. filtrationThe product was filtered off
7. washwashed with hexane
8. customdried