反应详情

温度

50 °C

Using the method of Fischer and Hurni (Arzneimittel Forsch., 1964;14:1301) 5.4 g (0.05 mol) of 2-amino-4-methylpyridine in 50 mL of pyridine at 10° C. was reacted with 10.3 g (0.05 mol) of 2-chlorosulfenylbenzoyl chloride. The mixture was heated to 50° C. and maintained at that temperature for 2 hours. The mixture was cooled to 25° C. and filtered. The solid was recrystallized from benzene to give 4.5 g of the title compound, mp 195°-196.5° C.

1. customat 10° C.
2. temperaturemaintained at that temperature for 2 hours
3. temperatureThe mixture was cooled to 25° C.
4. filtrationfiltered
5. customThe solid was recrystallized from benzene