反应详情

To the diol of Step 3 (36.56 g, 79.8 mmol) in 400 mL of CH2Cl2 was added tert-butyl-chlorodimethylsilane (18.21 g, 121 mmol), imidazole (10.97 g, 161 mmol) and 4-(dimethylamino)pyridine (0.988 g, 8.1 mmol) and the mixture was stirred at r.t. for 3 days. Toluene (400 mL) was then added and the product was filtered through silica with EtOAc:toluene 0:100 to 5:95. The title product was concentrated and stripped with toluene to remove any remaining silyl chloride.

1. filtrationthe product was filtered through silica with EtOAc:toluene 0:100 to 5:95
2. concentrationThe title product was concentrated
3. customto remove any remaining silyl chloride