Diazomethane → HCID 54471742, compound

HRID 326940Notes

Reaction equation

HRID 326940 reaction equation
[CH3:1][C:2]1([CH3:9])[CH2:8][CH2:7][O:6][C:4](=[O:5])[CH2:3]1.[IH:10].[N+](=[CH2:13])=[N-]>CC(O)=O>[CH3:1][C:2]([CH3:9])([CH2:8][CH2:7][I:10])[CH2:3][C:4]([O:6][CH3:13])=[O:5]

Participants

5

Reactant 3

HCID 9550DiazomethaneHCID 24841Hydrogen iodideHCID 2112602H-Pyran-2-one, tetrahydro-4,4-dimethyl-

Product 1

HCID 54471742HCID 54471742, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

3,3-dimethyl-δ-valerolactone was treated with HI in HOAc, followed by diazomethane to give methyl 3,3-dimethyl-5-iodo-pentanoate. This material and the aldehyde from U.S. Pat. No. 4,851,409, Example 24, Step 1 were assembled using Method L. The thiol was from Example 80, Step 4. This compound showed signals at m/e 548 (M+I) and 570 (M+Na) in a fast atom bombardment mass spectrometer (FAB-MS).

Sources & evidence

ORD record
ord-d8947ee5133d4305868afc0fea6e7e0d
Source dataset
uspto-grants-1993_12
Patent number
US05270324

Reaction notes

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