HuagongsheHuagongshe Chemistry Print Report · For research reference only
19-Hydroxytestosterone → Androst-4-en-17,19-diol-3-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 19-Hydroxytestosterone | HCID 150968 | — |
| Reactant | 19-Hydroxyandrostenedione | HCID 252379 | — |
| Reactant | Potassium borohydride | HCID 4192641 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | Androst-4-en-17,19-diol-3-one | HCID 22849351 | — |
Reaction Steps
Also known as 19-Hydroxytestosterone, this compound is commercially available from Steraloids, Inc. Alternatively, 19-hydroxyandrost-4-en-3,17-dione (11) is treated with potassium borohydride (KBH4, a) in ethanol at -10° to 0° C. Aqueous work up is followed by extraction and purification to yield 19-hydroxytestosterone (12).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05272134 |
| Source dataset | uspto-grants-1993_12 |
| ORD ID | ord-90602cc878724a59a9a209d969e464c5 |
| Source note | uspto-grants-1993_12 |