(2-Thienylmethyl)amine → HCID 19734532, compound

HRID 327097Notes

Reaction equation

HRID 327097 reaction equation
[C:1]([N:3]=[C:4]([C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][N:8]=1)OC)#[N:2].[S:13]1[CH:17]=[CH:16][CH:15]=[C:14]1[CH2:18][NH2:19]>CO>[C:1]([NH:3][C:4]([C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][N:8]=1)=[N:19][CH2:18][C:14]1[S:13][CH:17]=[CH:16][CH:15]=1)#[N:2]

Participants

4

Reactant 2

HCID 34005(2-Thienylmethyl)amineHCID 100121892-Pyridinecarboximidic acid, N-cyano-, methyl ester

Product 1

HCID 19734532HCID 19734532, compoundYield 54.8%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Methyl N-cyano-2-pyridinecarboximidate (0.50 g, 3.1 mmol) was dissolved in methanol (10 ml), 2-thiophenemethylamine (0.38 g, 3.4 mmol) was added, and the resulting mixture was stirred at room temperature for 40 minutes. After the reaction was completed, the reaction solution was . concentrated under reduced pressure, and the residue thus obtained was crystallized from dichloromethane diethyl ether to give the title compound (0.40 g, 1.7 mmol, yield: 54%) as colorless needles.

Workup

  1. concentrationconcentrated under reduced pressure
  2. customthe residue thus obtained
  3. customwas crystallized from dichloromethane diethyl ether

Sources & evidence

ORD record
ord-3c0996ed3c6f4bc2b1563d4ae34ceab8
Source dataset
uspto-grants-1993_12
Patent number
US05272164

Reaction notes

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