HCID 1360, compound → HCID 178492576, compound

HRID 327148Notes

Reaction equation

HRID 327148 reaction equation
[Cl:1][C:2]1[CH:19]=[C:18]([O:20][CH3:21])[CH:17]=[CH:16][C:3]=1[O:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][N:11]1[CH:15]=[CH:14][N:13]=[CH:12]1.[CH3:22][I:23]>C(Cl)Cl>[I-:23].[Cl:1][C:2]1[CH:19]=[C:18]([O:20][CH3:21])[CH:17]=[CH:16][C:3]=1[O:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][N+:11]1[CH:15]=[CH:14][N:13]([CH3:22])[CH:12]=1

Participants

4

Reactant 2

HCID 1360HCID 1360, compoundHCID 6328Methyl iodide

Product 1

HCID 178492576HCID 178492576, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Stir at room temperature for about 2.5 hours, 300 mg. of the compound prepared in Example 1, 5 ml. methylene chloride and 0.066 ml. methyl iodide. Elute on a coarse silica column with methylene chloride, then 5% methanol/methylene chloride and finally 10% methanol/methylene chloride, to isolate the title compound.

Workup

  1. washElute on a coarse silica column with methylene chloride

Sources & evidence

ORD record
ord-bd4e9426da714b9bbd5a3662ff897126
Source dataset
uspto-grants-1993_12
Patent number
US05272167

Reaction notes

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