反应详情

Combine sodium imidazole (5 g) and 8-bromo-1-octene (5 g) in DMF and stir overnight. Partition the reaction product between water and dichloromethane, evaporate the organic layer and purify the resultant residue on a silica gel column. Add the imidazole compound (4.6 g) and phenol (1 g) to dichloromethane (250 ml), saturate the solution with HBr gas and stir for 4 hours. Evaporate the solvent and wash the residue with THF: hexane (1:1) to obtain 1-(2-bromooctyl)imidazole hydrobromide.

1. customPartition the reaction product between water and dichloromethane
2. customevaporate the organic layer
3. custompurify the resultant residue on a silica gel column
4. additionAdd the imidazole compound (4.6 g) and phenol (1 g) to dichloromethane (250 ml)
5. concentrationsaturate the solution with HBr gas
6. customEvaporate the solvent
7. washwash the residue with THF: hexane (1:1)