Allyl bromide → 3-[N-Allyl-3-(4-chlorobenzyl)-6-(quinolin-2-ylmethoxy)-indol-2-yl]-2,2-dimethylpropanoic acid
Reaction equation
[CH2:1](Br)[CH:2]=[CH2:3].C1(S([N:14]2[C:22]3[C:17](=[CH:18][CH:19]=[C:20]([O:23][CH2:24][C:25]4[CH:34]=[CH:33][C:32]5[C:27](=[CH:28][CH:29]=[CH:30][CH:31]=5)[N:26]=4)[CH:21]=3)[C:16]([CH2:35][C:36]3[CH:41]=[CH:40][C:39]([Cl:42])=[CH:38][CH:37]=3)=[C:15]2[CH2:43][C:44]([CH3:50])([CH3:49])[C:45]([O:47]C)=[O:46])(=O)=O)C=CC=CC=1>>[CH2:1]([N:14]1[C:22]2[C:17](=[CH:18][CH:19]=[C:20]([O:23][CH2:24][C:25]3[CH:34]=[CH:33][C:32]4[C:27](=[CH:28][CH:29]=[CH:30][CH:31]=4)[N:26]=3)[CH:21]=2)[C:16]([CH2:35][C:36]2[CH:41]=[CH:40][C:39]([Cl:42])=[CH:38][CH:37]=2)=[C:15]1[CH2:43][C:44]([CH3:50])([CH3:49])[C:45]([OH:47])=[O:46])[CH:2]=[CH2:3]Participants
3
Procedure
The title compound was prepared under the conditions described in Step A and Step B of Example 38, but substituting allyl bromide for the benzenesulfonyl chloride from Example 38 (Step A).
Sources & evidence
- ORD record
- ord-68bb106446fa490eab9163da18952d8f
- Source dataset
- uspto-grants-1993_12
- Patent number
- US05272145
Reaction notes
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