反应详情

A solution of 1-bromohexane (9.33 g) in acetone (20 ml) is added dropwise to a stirred mixture of 4-bromo-3-fluorophenol (9.00 g) and potassium carbonate (13.5 g) in acetone 75 ml) at room temperature. The stirred mixture is heated under reflux for 21 h (i.e. until glc analysis revealed a complete reaction). The product is extracted into ether twice, and the combined ether extracts are washed with water, 10% sodium hydroxide, water and dried (MgSO4). The solvent is removed under vacuo and the residue is distilled (bp 100°-105° C. at 0.1 mm Hg) to yield a colourless liquid.

1. temperatureThe stirred mixture is heated
2. temperatureunder reflux for 21 h (i.e. until glc analysis
3. customa complete reaction)
4. extractionThe product is extracted into ether twice
5. washthe combined ether extracts are washed with water, 10% sodium hydroxide, water
6. dry with materialdried (MgSO4)
7. customThe solvent is removed under vacuo
8. distillationthe residue is distilled (bp 100°-105° C. at 0.1 mm Hg)
9. customto yield a colourless liquid