反应详情

A suspension of 2-(1-pyrrolidinylmethyl)-1-azabicyclo-[2.2.2]octan-3-one oxime (8.94 g, 40 mmoles) in methanol (250 ml) in a Parr bottle was treated with Raney Nickel and subjected to hydrogenation over 16 hours at 50-60 psi pressure. The resultant solution was filtered through Celite® under nitrogen, and concentrated in vacuo to provide 7.30 g (87%) of a colorless oil.

1. filtrationThe resultant solution was filtered through Celite® under nitrogen
2. concentrationconcentrated in vacuo