HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-(1-Pyrrolidinylmethyl)-1-azabicyclo[2.2.2]octan-3-one oxime → 2-(1-Pyrrolidinylmethyl)-1-azabicyclo[2.2.2]octan-3-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-(1-Pyrrolidinylmethyl)-1-azabicyclo[2.2.2]octan-3-one oxime | HCID 74001746 | — |
| Catalyst | Nickel | HCID 935 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 2-(1-Pyrrolidinylmethyl)-1-azabicyclo[2.2.2]octan-3-amine | HCID 19108419 | 87.2% |
Reaction Steps
A suspension of 2-(1-pyrrolidinylmethyl)-1-azabicyclo-[2.2.2]octan-3-one oxime (8.94 g, 40 mmoles) in methanol (250 ml) in a Parr bottle was treated with Raney Nickel and subjected to hydrogenation over 16 hours at 50-60 psi pressure. The resultant solution was filtered through Celite® under nitrogen, and concentrated in vacuo to provide 7.30 g (87%) of a colorless oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05273972 |
| Source dataset | uspto-grants-1993_12 |
| ORD ID | ord-1027ca3e9b594a659bf0c55084b41715 |
| Source note | uspto-grants-1993_12 |