Water → HCID 54387181, compound

HRID 327395Notes

Reaction equation

HRID 327395 reaction equation
[NH2:1][C@H:2]1[CH2:7][CH2:6][CH2:5][CH2:4][C@H:3]1[C:8]([N:10]1[CH2:15][CH2:14][CH:13]([CH3:16])[CH2:12][CH2:11]1)=O.O.[OH-].[Na+]>O1CCCC1>[CH3:16][CH:13]1[CH2:14][CH2:15][N:10]([CH2:8][C@H:3]2[CH2:4][CH2:5][CH2:6][CH2:7][C@H:2]2[NH2:1])[CH2:11][CH2:12]1

Participants

5

Reactant 3

HCID 962Water2×HCID 14798Sodium HydroxideHCID 53705508HCID 53705508, compound

Product 1

HCID 54387181HCID 54387181, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent2×

Procedure

1-[Cis-(2-aminocyclohexyl)carbonyl]-4-methylpiperidine (6.57 g; 0.0293 mol) is dissolved in tetrahydrofuran (25 ml) and added dropwise to a suspension of AlLiH4 (2.22 g; 0.0586 mol) in tetrahydrofuran (50 ml). At the end of the addition, the reaction mixture is refluxed for 24 h and then hydrolyzed by carefully adding water (2.3 ml), then a 15% sodium hydroxide solution (2.3 ml) and then water (5 ml).

Workup

  1. additionAt the end of the addition
  2. temperaturethe reaction mixture is refluxed for 24 h

Sources & evidence

ORD record
ord-ee598f44ded248fe8f4237979d343c83
Source dataset
uspto-grants-1993_12
Patent number
US05273983

Reaction notes

Loading…