HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Hydroxypiperidine → Rac-2-(3-hydroxy-piperidin-1-yl)-5-methylsulfamoyl-benzoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Hydroxypiperidine | HCID 23293 | — |
| Reactant | Benzoic acid, 2-chloro-5-[(methylamino)sulfonyl]- | HCID 111724 | — |
| Reactant | 5-Methanesulfonyl-2-pyrrolidin-1-yl-benzoic acid | HCID 59793489 | — |
| Product | Rac-2-(3-hydroxy-piperidin-1-yl)-5-methylsulfamoyl-benzoic acid | HCID 59793580 | 15% |
Reaction Steps
The title compound was synthesised according to the procedure described for the synthesis of 5-Methanesulfonyl-2-pyrrolidin-1-yl-benzoic acid (Example S) from 2-Chloro-5-methylsulfamoyl-benzoic acid and rac-3-hydroxy-piperidine and obtained in 15% yield. MS (m/e): 312.9 (MH− 100%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07427612B2 |
| Source dataset | uspto-grants-2008_09 |
| ORD ID | ord-36919d26d00f4ef1a0e891b347c58139 |
| Source note | uspto-grants-2008_09 |