Acetic Acid → HCID 11459998, compound

HRID 327468Notes

Reaction equation

HRID 327468 reaction equation
Cl[C:2]1[N:12]2[C:13]3[C:8]([CH2:9][CH:10]([N:14]([CH2:18][CH2:19][CH3:20])[CH2:15][CH2:16][CH3:17])[CH2:11]2)=[CH:7][CH:6]=[CH:5][C:4]=3[N:3]=1.C(O)(=[O:23])C>>[CH2:15]([N:14]([CH2:18][CH2:19][CH3:20])[CH:10]1[CH2:9][C:8]2[C:13]3=[C:4]([NH:3][C:2](=[O:23])[N:12]3[CH2:11]1)[CH:5]=[CH:6][CH:7]=2)[CH2:16][CH3:17]

Participants

3

Reactant 2

HCID 176Acetic AcidHCID 15291955HCID 15291955, compound

Product 1

HCID 11459998HCID 11459998, compound

Procedure

2-Chloro-5,6-dihydro-N,N-dipropyl-4H-imidazo(4,5,1-ij)quinolin-5-amine was refluxed in acetic acid for 1 hour. The solvent was removed and the residue was partitioned between ethyl acetate and sodium hydroxide solution. Evaporation of the ethyl acetate afforded 5-(dipropylamino)-5,6-dihydro-4H-imidazo(4,5,1-ij)quinoline-2(1H)-one.

Workup

  1. customThe solvent was removed
  2. customthe residue was partitioned between ethyl acetate and sodium hydroxide solution
  3. customEvaporation of the ethyl acetate

Sources & evidence

ORD record
ord-7937fc0ede174da9a189804e733b5833
Source dataset
uspto-grants-1993_12
Patent number
US05273975

Reaction notes

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