Morpholine → 5-(Aminosulfonyl)-2-morpholin-4-ylbenzoic acid

HRID 32748Notes

Reaction equation

HRID 32748 reaction equation
CS(C1C=CC(N2CCCC2)=C(C=1)C(O)=O)(=O)=O.Cl[C:20]1[CH:28]=[CH:27][C:26]([S:29](=[O:32])(=[O:31])[NH2:30])=[CH:25][C:21]=1[C:22]([OH:24])=[O:23].[NH:33]1[CH2:38][CH2:37][O:36][CH2:35][CH2:34]1>>[N:33]1([C:20]2[CH:28]=[CH:27][C:26]([S:29](=[O:32])(=[O:31])[NH2:30])=[CH:25][C:21]=2[C:22]([OH:24])=[O:23])[CH2:38][CH2:37][O:36][CH2:35][CH2:34]1

Participants

4

Reactant 3

HCID 8083MorpholineHCID 667942-Chloro-5-aminosulfonylbenzoic acidHCID 597934895-Methanesulfonyl-2-pyrrolidin-1-yl-benzoic acid

Product 1

HCID 49621165-(Aminosulfonyl)-2-morpholin-4-ylbenzoic acidYield 85%

Procedure

The title compound was synthesised according to the procedure described for the synthesis of 5-Methanesulfonyl-2-pyrrolidin-1-yl-benzoic acid (Example S) from 2-Chloro-5-sulfamoyl-benzoic acid (CAS: 97-04-1; Basu; D.-G.; J.Indian Chem.Soc.; 16; 1939; 100, 106) and morpholine and obtained in 85% yield. MS (m/e): 285.1 (MH− 100%).

Workup

  1. customobtained in 85% yield

Sources & evidence

ORD record
ord-6fd99190e7aa42438846a375d1701087
Source dataset
uspto-grants-2008_09
Patent number
US07427612B2

Reaction notes

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