Iodine → HCID 18934809, compound

HRID 3275Notes

Reaction equation

HRID 3275 reaction equation
[CH2:1]([NH:9][C:10]([C:12]1[C:13]([SH:24])=[N:14][C:15]([C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)=[N:16][CH:17]=1)=[O:11])[CH2:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1.II>>[CH2:1]([N:9]1[C:10](=[O:11])[C:12]2[C:13](=[N:14][C:15]([C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=3)=[N:16][CH:17]=2)[S:24]1)[CH2:2][C:3]1[CH:4]=[CH:5][CH:6]=[CH:7][CH:8]=1

Participants

3

Reactant 2

HCID 807IodineHCID 178418363HCID 178418363, compound

Product 1

HCID 18934809HCID 18934809, compoundYield 71.5%

Procedure

Using the procedure of Example 20, 2.0 g (5.96 mmol) of 4-mercapto-2-phenyl-pyrimidine-5-carboxylic acid phenethyl-amide were treated with 1.66 g (6.56 mmol) of iodine to give 1.42 g of the title compound after recrystallization from isopropanol, mp 144°-147° C.

Sources & evidence

ORD record
ord-156358fb63ab4966938ac93b299a8521
Source dataset
uspto-grants-1998_03
Patent number
US05733921

Reaction notes

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