反应详情

温度

10 °C

A mixture composed of 2.5 g of 4-(1-methylethyl)thiazole methanol, 6.3 g of triphenylphosphine, 2.2 g of imidazole and 100 ml of toluene was warmed until all of the solids dissolved. This solution was cooled to 10° C. and 6.1 g of iodine was added. After 2 hr, the mixture was washed with an excess of sodium thiosulfate solution. The aqueous layer was back extracted with ethyl ether and the combined organic layers were washed with brine and then dried (MgSO4). Removal of the solvents in vacuo yielded 5.0 g of 2-iodomethyl-4-(1-methylethyl)thiazole as an oil.

1. temperaturewas warmed until all of the solids
2. dissolutiondissolved
3. washthe mixture was washed with an excess of sodium thiosulfate solution
4. extractionThe aqueous layer was back extracted with ethyl ether
5. washthe combined organic layers were washed with brine
6. dry with materialdried (MgSO4)
7. customRemoval of the solvents in vacuo