4-Methylpyrazole → 3-Fluoro-4-{4-[5-methanesulfonyl-2-(4-methyl-pyrazol-1-yl)-benzoyl]-piperazin-1-yl}-benzonitrile

HRID 32767Notes

Reaction equation

[F:1][C:2]1[CH:3]=[C:4]([CH:7]=[CH:8][C:9]=1[N:10]1[CH2:15][CH2:14][N:13]([C:16](=[O:28])[C:17]2[CH:22]=[C:21]([S:23]([CH3:26])(=[O:25])=[O:24])[CH:20]=[CH:19][C:18]=2I)[CH2:12][CH2:11]1)[C:5]#[N:6].[CH3:29][C:30]1[CH:31]=[N:32][NH:33][CH:34]=1>>[F:1][C:2]1[CH:3]=[C:4]([CH:7]=[CH:8][C:9]=1[N:10]1[CH2:15][CH2:14][N:13]([C:16](=[O:28])[C:17]2[CH:22]=[C:21]([S:23]([CH3:26])(=[O:25])=[O:24])[CH:20]=[CH:19][C:18]=2[N:32]2[CH:31]=[C:30]([CH3:29])[CH:34]=[N:33]2)[CH2:12][CH2:11]1)[C:5]#[N:6]

Participants

Reactant 2

HCID 34064-Methylpyrazole

HCID 597935053-Fluoro4-[4-(2-iodo-5-methanesulfonyl-benzoyl)-piperazin-1-yl]-benzonitrile

Product 1

HCID 688446223-Fluoro-4-{4-[5-methanesulfonyl-2-(4-methyl-pyrazol-1-yl)-benzoyl]-piperazin-1-yl}-benzonitrileYield 20%

Procedure

The title compound was prepared according to the procedure described for example 294 from 3-Fluoro-4-[4-(2-iodo-5-methanesulfonyl-benzoyl)-piperazin-1-yl]-benzonitrile (compound CL) and 4-Methyl-1H-pyrazole (20% yield, white foam, MS (m/e): 468.3 (M+H, 100%)

Sources & evidence

ORD record: ord-883cf2c849314570ae2499c16cd1879d
Source dataset: uspto-grants-2008_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07427612B2

Reaction notes

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