HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Methylpyrazole → 3-Fluoro-4-{4-[5-methanesulfonyl-2-(4-methyl-pyrazol-1-yl)-benzoyl]-piperazin-1-yl}-benzonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Methylpyrazole | HCID 3406 | — |
| Reactant | 3-Fluoro4-[4-(2-iodo-5-methanesulfonyl-benzoyl)-piperazin-1-yl]-benzonitrile | HCID 59793505 | — |
| Product | 3-Fluoro-4-{4-[5-methanesulfonyl-2-(4-methyl-pyrazol-1-yl)-benzoyl]-piperazin-1-yl}-benzonitrile | HCID 68844622 | 20% |
Reaction Steps
The title compound was prepared according to the procedure described for example 294 from 3-Fluoro-4-[4-(2-iodo-5-methanesulfonyl-benzoyl)-piperazin-1-yl]-benzonitrile (compound CL) and 4-Methyl-1H-pyrazole (20% yield, white foam, MS (m/e): 468.3 (M+H, 100%)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07427612B2 |
| Source dataset | uspto-grants-2008_09 |
| ORD ID | ord-883cf2c849314570ae2499c16cd1879d |
| Source note | uspto-grants-2008_09 |