Methane → HCID 19108674, compound

HRID 327673Notes

Reaction equation

HRID 327673 reaction equation
[S:1](Cl)(=[O:4])(=[O:3])[NH2:2].[CH3:6][O:7][C:8]1[CH:17]=[CH:16][CH:15]=[CH:14][C:9]=1[O:10][CH2:11][CH2:12][OH:13].C>C(Cl)Cl>[S:1]([O:13][CH2:12][CH2:11][O:10][C:9]1[CH:14]=[CH:15][CH:16]=[CH:17][C:8]=1[O:7][CH3:6])(=[O:4])(=[O:3])[NH2:2]

Participants

5

Reactant 3

HCID 297MethaneHCID 24499Chlorosulfamic acidHCID 38041392-(2-methoxyphenoxy)ethanol

Product 1

HCID 19108674HCID 19108674, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

The title compound was prepared by the procedure of Example 33 from sulfamoyl chloride and 2-(2-methoxyphenoxy)ethanol. The solid obtained was dissolved in 150 ml of methylene chloride, and the solution was treated with charcoal and filtered through Celite®. The filtrate was evaporated under reduced pressure and the solid residue was recrystallized from methylene chloride-petroleum ether (bp range 30°-60° C.) to give the title compound in 25% yield as white solid, mp 102°-104° C.

Workup

  1. customThe solid obtained
  2. filtrationfiltered through Celite®
  3. customThe filtrate was evaporated under reduced pressure
  4. customthe solid residue was recrystallized from methylene chloride-petroleum ether (bp range 30°-60° C.)

Sources & evidence

ORD record
ord-5320188127f74e5aaf70c28c90815ae4
Source dataset
uspto-grants-1993_12
Patent number
US05273993

Reaction notes

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