反应详情

温度

60 °C

A mixture of 2-bromoacetophenone (199 g, 1.0M), acetic acid (200 mL) and acetic anhydride (30 mL) was stirred and heated to about 60° C. Anhydrous sodium acetate (100 g, 1.2M) was added and the reaction mixture was heated and stirred at about 130° C. for 6.0 hrs and then allowed to cool. To remove most of the salt, the reaction mixture was filtered through a sintered glass funnel. The acetic acid and acetic anhydride were removed from the filtrate using a rotary evaporator. A white solid was obtained upon cooling (yield--97.0 g). Mass spectroscopy supported the proposed structure.

1. temperaturethe reaction mixture was heated
2. stirringstirred at about 130° C. for 6.0 hrs
3. temperatureto cool
4. customTo remove most of the salt
5. filtrationthe reaction mixture was filtered through a sintered glass funnel
6. customThe acetic acid and acetic anhydride were removed from the filtrate
7. customa rotary evaporator
8. customA white solid was obtained
9. temperatureupon cooling
10. custom(yield--97.0 g)