反应详情

To a stirred solution of N-benzyloxycarbonyl-L-phenylalanine p-nitrophenyl ester (5.0 g, 11.9 mmol) in DCM at 0° C. was slowly added a solution of 8M methylamine (1.5 ml, 11.9 mmol) in ethanol. The reaction immediately turned bright yellow and was stirred for 0.5 h. The reaction was diluted with DCM (50 ml), washed with 10% sodium carbonate (1×50 ml), brine (2×50 ml) and dried over anhydrous magnesium sulphate. Filtration and evaporation gave a white residue which was crystallised from ethyl acetate/hexane to give N-benzyloxycarbonyl-L-phenylalanine methylamide (3.0 g, 81%) as a white crystalline solid.

1. customThe reaction immediately turned bright yellow
2. washwashed with 10% sodium carbonate (1×50 ml), brine (2×50 ml)
3. dry with materialdried over anhydrous magnesium sulphate
4. filtrationFiltration and evaporation
5. customgave a white residue which
6. customwas crystallised from ethyl acetate/hexane