Succinic Acid → HCID 131716353, compound

HRID 327919Notes

Reaction equation

HRID 327919 reaction equation
[CH:1]1([CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][N:16]([CH2:18][CH2:19][CH2:20][N:21]([CH3:23])[CH3:22])[CH3:17])[CH2:5][CH2:4][CH2:3][CH2:2]1.[C:24]([OH:31])(=[O:30])[CH2:25][CH2:26][C:27]([OH:29])=[O:28]>CO>[C:24]([OH:31])(=[O:30])[CH2:25][CH2:26][C:27]([OH:29])=[O:28].[C:24]([OH:31])(=[O:30])[CH2:25][CH2:26][C:27]([OH:29])=[O:28].[CH:1]1([CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][N:16]([CH2:18][CH2:19][CH2:20][N:21]([CH3:23])[CH3:22])[CH3:17])[CH2:5][CH2:4][CH2:3][CH2:2]1

Participants

4

Reactant 2

HCID 1110Succinic AcidHCID 54549389HCID 54549389, compound

Product 1

HCID 131716353HCID 131716353, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent2×

Procedure

The diamine of Example 40 (274 mg) in methanol (3 ml) is treated with succinic acid (283 mg) in methanol (3 ml). The reaction is stirred at 20°-25° for 18 hours. A white precipitate forms which is collected by filtration. This is then recrystallized from methanol-diethyl ether to give a solid, mp 164°-166° C. Second crop mp 164°-165° C. (PLA2)

Workup

  1. filtrationA white precipitate forms which is collected by filtration
  2. customThis is then recrystallized from methanol-diethyl ether
  3. customto give a solid, mp 164°-166° C

Sources & evidence

ORD record
ord-6dd7a439a5784d38b45b846bb3598124
Source dataset
uspto-grants-1993_12
Patent number
US05274089

Reaction notes

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