1,5-Dibromopentane → 2-[(5-Bromopentyl)oxy]-5-[[4-(ethoxycarbonyl)phenyl]carbonyl]benzenepropanoic Acid Ethyl Ester
Reaction equation
[CH2:1]([O:3][C:4](=[O:27])[CH2:5][CH2:6][C:7]1[CH:12]=[C:11]([C:13]([C:15]2[CH:20]=[CH:19][C:18]([C:21]([O:23][CH2:24][CH3:25])=[O:22])=[CH:17][CH:16]=2)=[O:14])[CH:10]=[CH:9][C:8]=1[OH:26])[CH3:2].[Br:28][CH2:29][CH2:30][CH2:31][CH2:32][CH2:33]Br>>[CH2:1]([O:3][C:4](=[O:27])[CH2:5][CH2:6][C:7]1[CH:12]=[C:11]([C:13]([C:15]2[CH:20]=[CH:19][C:18]([C:21]([O:23][CH2:24][CH3:25])=[O:22])=[CH:17][CH:16]=2)=[O:14])[CH:10]=[CH:9][C:8]=1[O:26][CH2:33][CH2:32][CH2:31][CH2:30][CH2:29][Br:28])[CH3:2]Participants
3
Procedure
Starting with 0.484 g (1.31 mmol) of 5-[[4-(ethoxycarbonyl)phenyl]carbonyl]-2-hydroxybenzenepropanoic acid ethyl ester, and 2.4 g (10.44 mmol) of 1,5-dibromopentane, the title compound was obtained in 72.6% yield as a white solid, mp 76.5°-78° C., using the procedure of example 21.
Sources & evidence
- ORD record
- ord-901ad28685db4a7fa12f1619c01f85c2
- Source dataset
- uspto-grants-1993_12
- Patent number
- US05273999
Reaction notes
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