Hydrogen Bromide → HCID 13890464, compound

HRID 328083Notes

Reaction equation

C(OC([NH:11][C@H:12]([C:20]([NH:22][CH2:23][P:24](=[O:29])([O:27]C)[O:25]C)=[O:21])[CH2:13][C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1)=O)C1C=CC=CC=1.Br>>[NH2:11][C@H:12]([C:20]([NH:22][CH2:23][P:24](=[O:25])([OH:29])[OH:27])=[O:21])[CH2:13][C:14]1[CH:15]=[CH:16][CH:17]=[CH:18][CH:19]=1

Participants

Reactant 2

HCID 260Hydrogen Bromide

HCID 54112343HCID 54112343, compound

Product 1

HCID 13890464HCID 13890464, compound

Procedure

In a manner analogous to Example 13(b), but with reaction of dimethyl [(N-benzyloxycarbonyl-L-phenylalanyl)-amino]-methylphosphonate and hydrogen bromide/glacial acetic acid for 2 hours, there was obtained (L-phenylalanylamino)methylphosphonic acid of melting point 266°-268° C (decomposition); [α]D20 = +74.5° (c = 0.8% in water).

Sources & evidence

ORD record: ord-87a2e0be26de454aa6d6344467d9b583
Source dataset: uspto-grants-1977_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04016148

Reaction notes

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