Benzylamine → HCID 54358335, compound

HRID 328096Notes

Reaction equation

HRID 328096 reaction equation
[CH2:1](N)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.C(OC([NH:19][C@H:20]([C:22]([NH:24][C@H:25]([P:27](=[O:30])([OH:29])[OH:28])C)=[O:23])[CH3:21])=O)C1C=CC=CC=1>CO>[NH2:19][C@H:20]([C:22]([NH:24][C@H:25]([P:27](=[O:28])([OH:30])[OH:29])[CH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1)=[O:23])[CH3:21]

Participants

4

Reactant 2

HCID 7504BenzylamineHCID 13002188HCID 13002188, compound

Product 1

HCID 54358335HCID 54358335, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

In a manner analogous to that given in Example 1 (b) but with ion-exchange in methanol, from the benzylamine salt of (1R)-1-[(N-benzyloxycarbonyl-L-alanyl)amino]-ethylphosphonic acid there was obtained (1R)-1-(L-alanylamino)-2-phenylethylphosphonic acid of melting point 250°-260° C (decomposition); [α]D20 = -40.3° (c = 0.21% in water).

Sources & evidence

ORD record
ord-661646a7756d45baaa5a4915a3f72838
Source dataset
uspto-grants-1977_04
Patent number
US04016148

Reaction notes

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