反应详情

To a solution of 2.8 g of 1-(m-nitrophenyl)quinazoline-2,4(1H, 3H)-dione and 20 ml of dimethylformamide was added 4.2 g of trimethyl phosphate and the whole was refluxed for 5 hours. After the reaction was complete, the solvent was distilled off from the reaction mixture under reduced pressure. To the residue thus obtained was added water to precipitate a crude product. This product was recrystallized from methanol to yield 2.4 g of 1-(m-nitrophenyl)-3-methylquinazoline-2,4(1H, 3H)-dione as colorless needles, melting at 241°-242° C.

1. temperaturethe whole was refluxed for 5 hours
2. distillationthe solvent was distilled off from the reaction mixture under reduced pressure
3. customTo the residue thus obtained
4. customto precipitate a crude product
5. customThis product was recrystallized from methanol