Aceton-methanol → 3-dimethylamino-11-methyl-1,3,4,14b-tetrahydro-2H-pyridino [1,2-d]-dibenzo[b,f](1,4)-oxazepine

HRID 328136Notes

Reaction equation

[CH3:1][N:2]([CH3:26])[CH:3]1[CH2:25][N:7]2[C:8]3[CH:20]=[C:19](C(F)(F)F)[CH:18]=[CH:17]C=3S[C:11]3[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=3[CH:6]2[CH2:5][CH2:4]1.[CH3:27][OH:28].[CH3:29]C(C)=O>>[CH3:26][N:2]([CH3:1])[CH:3]1[CH2:25][N:7]2[C:8]3[CH:20]=[CH:19][CH:18]=[CH:17][C:27]=3[O:28][C:13]3[C:14]([CH3:29])=[CH:15][CH:16]=[CH:11][C:12]=3[CH:6]2[CH2:5][CH2:4]1

Participants

Reactant 2

HCID 21894497Aceton-methanol

HCID 706374283-dimethylamino-7-trifluoromethyl-1,3,4,14b-tetrahydro-2H-pyridino[1,2-d]-dibenzo[b,f](1,4)-thiazepine

Product 1

HCID 706378763-dimethylamino-11-methyl-1,3,4,14b-tetrahydro-2H-pyridino [1,2-d]-dibenzo[b,f](1,4)-oxazepine

Procedure

Rf in methanol:acetone (8:2) = 0.20 (equatorial). 3-dimethylamino-7-trifluoromethyl-1,3,4,14b-tetrahydro-2H-pyridino[ 1,2-d]-dibenzo[b,f](1,4)-thiazepine:

Sources & evidence

ORD record: ord-aefcbfa6dd4247baacbf836c92cfd0f5
Source dataset: uspto-grants-1977_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04016161

Reaction notes

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