反应详情

Cooling in an ice bath 0.93 g (5 mmol) of 1-(p-ethylphenoxy)-butan- 2-ol was dissolved in 10 ml of pyridine, and to this solution was added dropwise 0.53 g (5 mmol) of isobutyryl chloride. The mixture was stirred at room temperature for 3 hours after the addition was completed. The reaction mixture was treated in the same manner as in Example 7, and purified by column chromatography using silica gel to afford 1.3 g of 1 -(p-ethylphenoxy)-butan-2-ol isobutyrate (compound No. 15) in a yield of 83% as a colorless oily substance. The refractive index of the product was nD32 = 1.4799.

1. additionafter the addition
2. additionThe reaction mixture was treated in the same manner as in Example 7
3. custompurified by column chromatography