反应详情

To a suspension of anhydrous aluminum chloride (467 g,; 3.5 moles) in carbon tetrachloride (2 l.) is added acetyl chloride (275 g.; 249 cc., 3.5 moles) during 15 minutes with vigorous stirring and cooling in an ice-bath. Cyclohexylbenzene (481 g.; 3.0 moles) is added dropwise over a period of 3 hours, keeping the temperature below 5°. After addition is complete, the product is stirred for another hour before hydrolyzing by pouring into ice and hydrochloric acid with stirring. The organic phase is washed with successive portions of dilute hydrochloric acid, sodium carbonate, and water, and distilled to give p-cyclohexylacetophenone, (b.p. 88°-95.5°/ 0.05 mm.).

1. temperaturecooling in an ice-bath
2. customthe temperature below 5°
3. additionAfter addition
4. stirringthe product is stirred for another hour before hydrolyzing
5. stirringwith stirring
6. washThe organic phase is washed with successive portions of dilute hydrochloric acid, sodium carbonate, and water
7. distillationdistilled