HuagongsheHuagongshe Chemistry Print Report · For research reference only
(1,1'-Biphenyl)-2-carboxaldehyde → 2,6-Diamino-4-(biphenyl-2-yl)-1,4-dihydropyridine-3,5-dicarboxylic acid diethyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (1,1'-Biphenyl)-2-carboxaldehyde | HCID 121052 | — |
| Reactant | Carbamimidoyl-acetic acid ethyl ester | HCID 4599837 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 2,6-Diamino-4-(biphenyl-2-yl)-1,4-dihydropyridine-3,5-dicarboxylic acid diethyl ester | HCID 70631644 | 33% |
Reaction Steps
Upon heating a solution of 9.1 g biphenyl-2-aldehyde and 13.0 g amidinoacetic acid ethyl ester in 200 ml ethanol for two hours, 2,6-diamino-4-(biphenyl-2-yl)-1,4-dihydropyridine-3,5-dicarboxylic acid diethyl ester of m.p. 215° (ethanol) is obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04016277 |
| Source dataset | uspto-grants-1977_04 |
| ORD ID | ord-cca57af9b6a948d3bc0cac57d86293ef |
| Source note | uspto-grants-1977_04 |