Morpholine → HCID 21444968, compound

HRID 328236Notes

Reaction equation

HRID 328236 reaction equation
[N:1]1([C:6]2[CH:16]=[CH:15][CH:14]=[CH:13][C:7]=2[O:8][CH2:9][CH:10]2[O:12][CH2:11]2)[CH:5]=[CH:4][CH:3]=[CH:2]1.[NH:17]1[CH2:22][CH2:21][O:20][CH2:19][CH2:18]1>C(O)(C)C>[O:20]1[CH2:21][CH2:22][N:17]([CH2:11][CH:10]([OH:12])[CH2:9][O:8][C:7]2[CH:13]=[CH:14][CH:15]=[CH:16][C:6]=2[N:1]2[CH:5]=[CH:4][CH:3]=[CH:2]2)[CH2:18][CH2:19]1

Participants

4

Reactant 2

HCID 8083MorpholineHCID 137555101-{2-[(Oxiran-2-yl)methoxy]phenyl}-1H-pyrrole

Product 1

HCID 21444968HCID 21444968, compound

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent

Procedure

A solution of 15 g of 1-[o-(pyrrol-1-yl)-phenoxy]-2,3-epoxy-propane and 7 g of morpholine in 150 ml of isopropanol is heated for 2 hours to the boil under reflux. After evaporation in vacuo, an oil remains, which crystallises and after recrystallisation from butanone gives 1-morpholino-3-[o-(pyrrol-1-yl)-phenoxy]-2-propanol of melting point 81°-82° C. It forms a neutral fumarate of melting point 136°-137° C (from butanone).

Workup

  1. temperatureunder reflux
  2. customAfter evaporation in vacuo
  3. customwhich crystallises
  4. customafter recrystallisation from butanone

Sources & evidence

ORD record
ord-8380fcd96206467aac486d3058a9c266
Source dataset
uspto-grants-1977_04
Patent number
US04016283

Reaction notes

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