Isopropylamine → HCID 21444967, compound

HRID 328237Notes

Reaction equation

HRID 328237 reaction equation
[CH3:1][C:2]1[N:3]([C:8]2[CH:18]=[CH:17][CH:16]=[CH:15][C:9]=2[O:10][CH2:11][CH:12]2[O:14][CH2:13]2)[C:4]([CH3:7])=[CH:5][CH:6]=1.[CH:19]([NH2:22])([CH3:21])[CH3:20]>C(O)(C)C>[CH3:1][C:2]1[N:3]([C:8]2[CH:18]=[CH:17][CH:16]=[CH:15][C:9]=2[O:10][CH2:11][CH:12]([OH:14])[CH2:13][NH:22][CH:19]([CH3:21])[CH3:20])[C:4]([CH3:7])=[CH:5][CH:6]=1

Participants

4

Reactant 2

HCID 6363IsopropylamineHCID 9834699HCID 9834699, compound

Product 1

HCID 21444967HCID 21444967, compound

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent

Procedure

30 g of 1-[o-(2,5-dimethyl-pyrrol-1-yl)-phenoxy]-2,3-epoxy-propane, dissolved in 200 ml of isopropanol, are mixed with 60 ml of isopropylamine and the mixture is heated to the boil under reflux for 2 hours. The oil which remains after evaporation is recrystallised from petroleum ether with addition of active charcoal and gives 1-[o-(2,5-dimethyl-pyrrol-1-yl)-phenoxy]-3-isopropylamino2-propanol of melting point 73°-75° C. Its neutral fumarate melts at 186°-188° C (from acetone).

Workup

  1. temperaturethe mixture is heated to the boil
  2. temperatureunder reflux for 2 hours
  3. customafter evaporation
  4. customis recrystallised from petroleum ether with addition of active charcoal

Sources & evidence

ORD record
ord-a097b4ef6b6644a38cb1543c3eb0c352
Source dataset
uspto-grants-1977_04
Patent number
US04016283

Reaction notes

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