Formaldehyde → HCID 21444650, compound

HRID 328252Notes

Reaction equation

HRID 328252 reaction equation
[ClH:1].[C:2]1([C:8]2([OH:14])[CH2:13][CH2:12][NH:11][CH2:10][CH2:9]2)[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[C:15]1(=[O:25])[C:24]2[C:19](=[CH:20][CH:21]=[CH:22][CH:23]=2)[CH2:18][CH2:17][CH2:16]1.[CH2:26]=O>C(O)C>[ClH:1].[C:2]1([C:8]2([OH:14])[CH2:13][CH2:12][N:11]([CH2:26][CH:16]3[CH2:17][CH2:18][C:19]4[C:24](=[CH:23][CH:22]=[CH:21][CH:20]=4)[C:15]3=[O:25])[CH2:10][CH2:9]2)[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

5

Reactant 3

HCID 712FormaldehydeHCID 107241-TetraloneHCID 186143834-Phenylpiperidin-4-ol hydrochloride

Product 1

HCID 21444650HCID 21444650, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

21.35 g. of 4-phenylpiperidin-4-ol hydrochloride, 14.6 g. of 1-tetralone and 10 ml. of 37% formaldehyde solution in 50 ml. of ethanol are heated under reflux for 1 hour. The mixture is evaporated and ether is added to the residue, after which the phases are separated by decantation to give 2-(4-phenyl-4-hydroxypiperidinomethyl)-1-tetralone hydrochloride; m.p. 164°-167°.

Workup

  1. temperatureunder reflux for 1 hour
  2. customThe mixture is evaporated
  3. additionether is added to the residue
  4. customafter which the phases are separated by decantation

Sources & evidence

ORD record
ord-2a2bf1ea33f34d9f9595fc7766c7d132
Source dataset
uspto-grants-1977_04
Patent number
US04016281

Reaction notes

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