HuagongsheHuagongshe Chemistry Print Report · For research reference only
Formaldehyde → HCID 21444650, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Formaldehyde | HCID 712 | — |
| Reactant | 1-Tetralone | HCID 10724 | — |
| Reactant | 4-Phenylpiperidin-4-ol hydrochloride | HCID 18614383 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | HCID 21444650 | HCID 21444650 | — |
Reaction Steps
21.35 g. of 4-phenylpiperidin-4-ol hydrochloride, 14.6 g. of 1-tetralone and 10 ml. of 37% formaldehyde solution in 50 ml. of ethanol are heated under reflux for 1 hour. The mixture is evaporated and ether is added to the residue, after which the phases are separated by decantation to give 2-(4-phenyl-4-hydroxypiperidinomethyl)-1-tetralone hydrochloride; m.p. 164°-167°.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04016281 |
| Source dataset | uspto-grants-1977_04 |
| ORD ID | ord-2a2bf1ea33f34d9f9595fc7766c7d132 |
| Source note | uspto-grants-1977_04 |