HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Carbonate → HCID 21444650, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | Phosphorus trichloride | HCID 24387 | — |
| Reactant | 4-Phenylpiperidin-1-ol | HCID 18412276 | — |
| Reactant | 2-(hydroxymethyl)-3,4-dihydronaphthalen-1(2H)-one | HCID 21444507 | — |
| Reactant | 2-Chloromethyl-1-tetralone | HCID 22325038 | — |
| Solvent | Isopropanol | HCID 3776 | — |
| Product | HCID 21444650 | HCID 21444650 | — |
Reaction Steps
1.95 g. of 2-chloromethyl-1-tetralone, prepared by reaction of phosphorus trichloride and 2-hydroxymethyl-1-tetralone, 3.54 g. of 4-phenylpiperidin-1-ol and 1 g. of potassium carbonate in 20 ml. of isopropanol are heated under reflux for 3 hours. The mixture is evaporated and worked up with water and ether to give 2-(4-phenyl-4-hydroxypiperidinomethyl)-1-tetralone. Hydrochloride, M.P. 164°-167°.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04016281 |
| Source dataset | uspto-grants-1977_04 |
| ORD ID | ord-4937bb5e7fea4bf7833dafed6a1d0cf6 |
| Source note | uspto-grants-1977_04 |