反应详情

1.95 g. of 2-chloromethyl-1-tetralone, prepared by reaction of phosphorus trichloride and 2-hydroxymethyl-1-tetralone, 3.54 g. of 4-phenylpiperidin-1-ol and 1 g. of potassium carbonate in 20 ml. of isopropanol are heated under reflux for 3 hours. The mixture is evaporated and worked up with water and ether to give 2-(4-phenyl-4-hydroxypiperidinomethyl)-1-tetralone. Hydrochloride, M.P. 164°-167°.

1. temperatureunder reflux for 3 hours
2. customThe mixture is evaporated