Acetonitrile → 1-(But-2-en-1-yl)piperazine

HRID 328283Notes

Reaction equation

HRID 328283 reaction equation
ClC1N=C2C(C=[CH:7][C:8]([N:12]3[CH:20](OC(OC4C=CC=CC=4)=O)[C:19]4[C:14](=CC=[CH:17][CH:18]=4)[C:13]3=O)=N2)=CC=1.C(#[N:34])C>>[CH2:20]([N:12]1[CH2:8][CH2:7][NH:34][CH2:14][CH2:13]1)[CH:19]=[CH:18][CH3:17]

Participants

3

Reactant 2

HCID 6342AcetonitrileHCID 233436372-(7-Chloro-1,8-naphthyridin-2-yl)-3-phenoxycarbonyloxy-1-isoindolinone

Product 1

HCID 539530791-(But-2-en-1-yl)piperazine

Procedure

Following the procedure of Example 36 but starting from 2-(7-chloro-1,8-naphthyridin-2-yl)-3-phenoxycarbonyloxy-1-isoindolinone (4.32 g.) and 1-(but-2-en-1-yl)-piperazine (7 g.) in acetonitrile (25 cc.), 3-[4-(but-2-en-1-yl)-1-piperazinyl]-carbonyloxy-2-(7-chloro-1,8-naphthyridin-2-yl)-1-isoindolinone (1.95 g.) melting at 190° C is obtained.

Sources & evidence

ORD record
ord-da0cbc45e86e4bbfb01e57d01bb62060
Source dataset
uspto-grants-1977_04
Patent number
US04016274

Reaction notes

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